Analysis of macromolecular/small-molecule binding pockets can provide important insights
into molecular recognition and receptor dynamics. Since its release in 2011, the POVME …

The proinflammatory cytokine interferon (IFN) γ activates GTP-cyclohydrolase I. In turn, the
production of neopterin in human monocytic cells and of 5, 6, 7, 8-tetrahydrobiopterin (BH4) …

Ischemic stroke is a serious public health problem worldwide. Here, we characterized the
metabolite features of acute ischemic stroke (AIS) using a gas chromatography-mass …

Higher serum neopterin is associated with increased mortality in patients with coronary
artery disease (CAD). Preferentially Th1‐type cytokine interferon‐γ stimulates neopterin …

TNF is a pleotropic cytokine known to be involved in the progression of several pro-
inflammatory disorders. Many therapeutic agents have been designed to counteract the …

Protein dynamics is essential to understand protein function and stability, even though is
rarely investigated as the origin of loss-of-function due to genetic variations. Here, we use …

Hepatic fibrosis is a classic pathological manifestation of metabolic chronic hepatopathy.
The pathological process might either gradually deteriorate into cirrhosis and ultimately liver …

Human proteins are vulnerable towards disease-associated single amino acid replacements
affecting protein stability and function. Interestingly, a few studies have shown that …

Chronic kidney disease (CKD) is the end point of a number of systemic chronic diseases.
The prevalence of CKD is increasing worldwide and recent epidemiological studies are …

Albuminuria is a measurement and determinant factor for diabetic kidney disease (DKD).
Angiotensin receptor blocker (ARB) is recommended for albuminuria in DKD with variable …