Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

With a worldwide prevalence of 15%, chronic constipation is one of the most frequent
gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source …

Many species, including humans, host communities of symbiotic microbes. There is a vast
literature on the ways these microbiomes affect hosts, but here we argue for an increased …

The act of defaecation, although a ubiquitous human experience, requires the coordinated
actions of the anorectum and colon, pelvic floor musculature, and the enteric, peripheral and …

Background and aims Gut transit time is a key modulator of host–microbiome interactions,
yet this is often overlooked, partly because reliable methods are typically expensive or …

The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-
triggered release approach has several advantages over other approaches due to unique …

Personalised dietary modulation of the gut microbiota may be key to disease management.
Current investigations provide a broad understanding of the impact of diet on the …

ABSTRACT BACKGROUND Chronic constipation is a prevalent disorder that affects
patients' quality of life and consumes resources in healthcare systems worldwide. In clinical …