Combination drugs are an important class of US FDA approved pharmaceuticals. These
drugs have been on a continuous growth trajectory since the first combination drugs were …

Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

This review summarizes synthetic developments reported from 1987 to 2019 that exploit C–
C single bond cleavage of cyclopropylamine-based systems. The synthetic and mechanistic …

Drug-induced liver injury (DILI) is the major cause for liver failure and post-marketing drug
withdrawals. Due to species-specific differences in hepatocellular function, animal …

A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Antibiotics used by general practitioners frequently appear in adverse-event reports of drug-
induced hepatotoxicity. Most cases are idiosyncratic (the adverse reaction cannot be …

Solar energy is clean, abundant, and more importantly, renewable. As such, any reaction
that efficiently harvests and converts solar energy into chemical energy is more important …

Polymorphonuclear leukocytes (PMNs) are important players in innate and acquired
immunity. These cells accumulate at inflammatory sites and contribute to host defence …

A number of drugs have been withdrawn from the market or severely restricted in their use
because of unexpected toxicities that become apparent only after the launch of new drug …

Applications of piperazine and homopiperazine in drug design are well-established, and
these heterocycles have found use as both scaffolding and terminal elements and also as a …