Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …

The circadian rhythm affects multiple physiological processes, and disruption of the
circadian system can be involved in a range of disease-related pathways. The genetic …

Circadian clock disorder during tissue degeneration has been considered the potential
pathogenesis for various chronic diseases, such as intervertebral disc degeneration (IVDD) …

The time of day strongly influences adaptive behaviors like long-term memory, but the
correlating synaptic and molecular mechanisms remain unclear. The circadian clock …

Adult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that
plays an important role in hippocampal function. Various mechanisms have been implicated …

The cortical microenvironment surrounding malignant glioblastoma is a source of
depolarizing crosstalk favoring hyperexcitability, tumor expansion, and immune evasion …

Circadian rhythms are self-sustained oscillations of biological systems that allow an
organism to anticipate periodic changes in the environment and optimally align feeding …

The advent of artificial lighting, particularly during the evening and night, has significantly
altered the predictable daily light and dark cycles in recent times. Altered light environments …

Many types of neurons exhibit a daily rhythm of intrinsic excitability. Here, we present a
protocol for assessing circadian regulation of dentate granule cell excitability using a mouse …

Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN),
in concert with local clocks throughout the body. While many brain regions exhibit cycling …