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Genetic and genomic studies, including genome-wide association studies (GWAS) have
accelerated the discovery of genes contributing to glaucoma, the leading cause of …

Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …

Until recently, very little was known about the molecular mechanisms responsible for the
development of glaucoma, a leading cause of blindness worldwide. Mutations in the …

Glaucoma is a heterogeneous eye disease and a major cause of blindness worldwide.
Recently, primary open angle glaucoma (POAG)-associated mutations have been found in …

Glaucoma can be inherited as a mendelian autosomal-dominant or autosomal-recessive
trait, or as a complex multifactorial trait. Genetic approaches have helped define the …

Genetic factors have long been implicated in the pathophysiology of primary open-angle
glaucoma (POAG). Recently, myocilin, a gene of unknown function, was associated with …

Mutations in the MYOC gene that encodes for myocilin are causative for some forms of
juvenile and adult-onset primary open-angle glaucoma (POAG). Myocilin is a secreted 55 …

MYOC encoding a 55kDa secretory glycoprotein named myocilin is closely linked to primary
open-angle glaucoma (POAG). To understand a role played by MYOC in glaucoma, we …

Glaucoma is a progressive blinding disease characterized by gradual loss of vision due to
optic neuropathy and retinal ganglion cell death. Increased intraocular pressure is a …