Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family
and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to …

Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a
common cause and outcome of organ failure and even death. Researchers have made …

Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular
abnormalities, immunological alterations and fibrosis of the skin and internal organs. The …

Background Monocytes/macrophages participate in cardiovascular disease. CD163 (cluster
of differentiation 163) is a monocyte/macrophage receptor, and the shed sCD163 (soluble …

With unknown etiology, scleroderma (SSc) is a multifaceted disease characterized by
immune activation, vascular complications, and excessive fibrosis in internal organs …

Systemic sclerosis (SSc) is a clinically heterogeneous disorder of the connective tissue
characterized by vascular alterations, immune/inflammatory manifestations, and organ …

Systemic sclerosis (SSc) is an autoimmune disease characterized by abnormalities in
microcirculation, extracellular matrix accumulation, and immune activation. Autoantibodies …

Our understanding of the mechanisms underlying HLA associations with inflammatory
arthritis continues to evolve. Disease associations have been refined, and interactions of …

Systemic sclerosis (SSc) is a rare connective tissue disease characterized by vascular
remodeling, fibroblast activation and extra-cellular matrix production in excess and …

Fibrotic disease, which is implicated in almost half of all deaths worldwide, is the result of an
uncontrolled wound healing response to injury in which tissue is replaced by deposition of …