International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Descending control of pain
MJ Millan - Progress in neurobiology, 2002 - Elsevier
Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …
information from the viscera, skin and other organs is subject to extensive processing by a …
Physiology and pathophysiology of itch
F Cevikbas, EA Lerner - Physiological reviews, 2020 - journals.physiology.org
Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …
understood and appreciated. The pathophysiological consequences of itch impact quality of …
The complex role of serotonin and 5-HT receptors in chronic pain
L Bardin - Behavioural pharmacology, 2011 - journals.lww.com
Abstract Serotonin [5-hydroxytryptamine (5-HT)] in the central nervous system and in the
periphery has long been considered to have an important role in the control of pain, for …
periphery has long been considered to have an important role in the control of pain, for …
Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy
Z Song, BA Meyerson, B Linderoth - PAIN®, 2011 - Elsevier
Spinal cord stimulation (SCS) is extensively employed in the management of neuropathic
pain, but the underlying mechanisms are only partially understood. Recently, we …
pain, but the underlying mechanisms are only partially understood. Recently, we …
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor
A Levit Kaplan, RT Strachan, JM Braz… - Journal of medicinal …, 2022 - ACS Publications
The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists
exist, remains the least understood serotonin receptor. A single commercial antagonist, SB …
exist, remains the least understood serotonin receptor. A single commercial antagonist, SB …
Molecular and cellular mechanisms that initiate pain and itch
Somatosensory neurons mediate our sense of touch. They are critically involved in
transducing pain and itch sensations under physiological and pathological conditions, along …
transducing pain and itch sensations under physiological and pathological conditions, along …
Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats
CY Jeong, JI Choi, MH Yoon - European journal of pharmacology, 2004 - Elsevier
The contribution of 5-HT (5-hydroxytryptamine) receptor subtypes to the antinociception
produced by intrathecal 5-HT in the formalin test was investigated in rats. Intrathecal 5-HT …
produced by intrathecal 5-HT in the formalin test was investigated in rats. Intrathecal 5-HT …
Monoamines as drug targets in chronic pain: focusing on neuropathic pain
Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …
and central monoaminergic dysfunction has been demonstrated in certain types of pain …
Characterization of endogenous calcium responses in neuronal cell lines
An increasing number of putative therapeutic targets have been identified in recent years for
the treatment of neuronal pathophysiologies including pain, epilepsy, stroke and …
the treatment of neuronal pathophysiologies including pain, epilepsy, stroke and …