Metabolic benefits afforded by estradiol and testosterone in both sexes: clinical considerations

F Mauvais-Jarvis, SH Lindsey - The Journal of Clinical Investigation, 2024 - jci.org
Testosterone (T) and 17β-estradiol (E2) are produced in male and female humans and are
potent metabolic regulators in both sexes. When E2 and T production stops or decreases …

[HTML][HTML] Sex and Gender Differences in Liver Fibrosis: Pathomechanisms and Clinical Outcomes

M Jamalinia, A Lonardo, R Weiskirchen - Fibrosis, 2024 - sciepublish.com
The accumulation of extracellular matrix proteins is the hallmark of liver fibrosis associated
with all chronic liver disease (CLD) types. Liver fibrosis results from repeated bouts of liver …

[HTML][HTML] Patient and caregiver perspectives on gender disparity in chronic kidney disease: Questionnaire survey, based on an interview study

L Vanek, D Gülmez, A Kurnikowski, S Krenn… - American Journal of …, 2024 - karger.com
Introduction: Chronic kidney disease (CKD) in stages 3–5 without albuminuria occurs more
often in women than in men; however, most patients initiating and receiving kidney …

Gender-affirming hormone therapy: effects on cardiovascular risk and vascular function

KA McGinley, AK Lucas-Herald… - Endocrine …, 2025 - ec.bioscientifica.com
Graphical abstract Gender-affirming hormone therapy and cardiovascular disease risk in
transgender individuals. CIMT, carotid intima–media thickness. CVD, cardiovascular …

Cross-Sex Hormone Therapy Is Associated With Loss of Circadian Rhythm in the Male Rat

JH Mallette, BF Crudup, A Oudomrath Speyrer… - …, 2024 - ahajournals.org
BACKGROUND: Transgender women are individuals born male but identify as female.
Many transgender women undergo gender-affirming hormone therapy to alleviate the …

Sex differences in ectopic lipid deposits and cardiac function across a wide range of glycemic control: a secondary analysis

J Harreiter, I Just, M Weber, R Klepochová, M Bastian… - …, 2024 - Wiley Online Library
Objective The objective of this study was to identify sex differences in ntrahepatocellular
(HCL) and intramyocardial lipids (MYCL) and cardiac function in participants with different …

[HTML][HTML] Incidence of Type 2 Diabetes Mellitus in Transgender Individuals Undergoing Gender Affirming Hormonal Therapy: A Systematic Review

P Panday, S Ejaz, S Gurugubelli, SK Prathi… - Cureus, 2024 - ncbi.nlm.nih.gov
Gender-affirming hormonal therapy (GAHT), which includes estrogen, testosterone,
androgen agonists, is commonly used in transgender individuals to change their secondary …

Sex differences in hepatic and cardiac lipid accumulation and cardiac function across a cohort with a wide range of glycemic control: A secondary, cross-sectional …

J Harreiter, I Just, M Weber, R Klepochová, M Bastian… - 2024 - researchsquare.com
Background: Sex differences in diabetes, obesity, metabolic disorders and cardiovascular
disease are well described, however, differences between women and men in …