Roles of the unsaturated fatty acid docosahexaenoic acid in the central nervous system: Molecular and cellular insights

AB Petermann, M Reyna-Jeldes, L Ortega… - International journal of …, 2022 - mdpi.com
Fatty acids (FAs) are essential components of the central nervous system (CNS), where they
exert multiple roles in health and disease. Among the FAs, docosahexaenoic acid (DHA) …

Exploring the role of nutraceuticals in major depressive disorder (MDD): Rationale, state of the art and future prospects

MA Alvarez-Mon, MA Ortega, C García-Montero… - Pharmaceuticals, 2021 - mdpi.com
Major depressive disorder (MDD) is a complex and common disorder, with many factors
involved in its onset and development. The clinical management of this condition is …

Dissecting the relationship between neuropsychiatric and neurodegenerative disorders

R Gupta, D Advani, D Yadav, RK Ambasta… - Molecular …, 2023 - Springer
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

DHA and EPA Prevent Seizure and Depression‐Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode‐of‐Actions in a Pentylenetetrazole …

X Wang, A Xiao, Y Yang, Y Zhao… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope It has been reported that eicosapentaenoic acid (EPA) and docosahexaenoic acid
(DHA) have anticonvulsant effects, yet the respective mechanism of EPA and DHA on …

Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation‐induced behaviour, biochemical and selected gut …

J Dhaliwal, DP Singh, S Singh… - Journal of applied …, 2018 - academic.oup.com
Aim Here, we evaluated any beneficial effects of a potential probiotic bacterial strain
(Lactobacillus plantarum MTCC 9510) in two different stress paradigms in mice. Methods …

mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior

X Li, ZJ Du, JN Xu, ZM Liang, S Lin, H Chen… - …, 2023 - nature.com
Pharmacological manipulation of mGluR5 has showed that mGluR5 is implicated in the
pathophysiology of anxiety and mGluR5 has been proposed as a potential drug target for …

Early-life stress alters synaptic plasticity and mTOR signaling: correlation with anxiety-like and cognition-related behavior

A Wang, X Zou, J Wu, Q Ma, N Yuan, F Ding, X Li… - Frontiers in …, 2020 - frontiersin.org
Early-life stress (ELS) predisposes individuals to psychiatric disorders, including anxiety and
depression, and cognitive impairments later in life. However, the underlying molecular …

PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies

M Di Miceli, C Bosch-Bouju, S Layé - Proceedings of the Nutrition …, 2020 - cambridge.org
PUFA of the n-3 and n-6 families are present in high concentration in the brain where they
are major components of cell membranes. The main forms found in the brain are DHA (22: 6 …

Theanine, the main amino acid in tea, prevents stress-induced brain atrophy by modifying early stress responses

K Unno, A Sumiyoshi, T Konishi, M Hayashi, K Taguchi… - Nutrients, 2020 - mdpi.com
Chronic stress can impair the health of human brains. An important strategy that may prevent
the accumulation of stress may be the consumption of functional foods. When senescence …

A Compared Study of Eicosapentaenoic Acid and Docosahexaenoic Acid in Improving Seizure-Induced Cognitive Deficiency in a Pentylenetetrazol-Kindling Young …

Y Yang, X Wang, L Chen, S Wang, J Han, Z Wang… - Marine Drugs, 2023 - mdpi.com
Epilepsy is a chronic neurological disorder that is more prevalent in children, and recurrent
unprovoked seizures can lead to cognitive impairment. Numerous studies have reported the …