The phenomenon of antigen processing and presentation and the concept that T cells
recognize peptides resulting from the partial catabolism of proteins, are relatively new …

The activation of helper T cells by peptides bound to proteins of the class II Major
Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The …

Cancers frequently evade cytotoxic T lymphocyte–mediated destruction through loss or
down-regulation of tumor antigens and antigen-presenting major histocompatibility complex …

We have determined the structure of murine MHC class II IA k in complex with a naturally
processed peptide from hen egg lysozyme (HEL residues 50–62) at 1.9 Å resolution. These …

Naturally processed MHC class II–bound peptides possess ragged NH 2 and COOH termini.
It is not known whether these peptide flanking residues (PFRs), which lie outside the MHC …

Peptides bind to MHC class II molecules with a defined periodicity such that the peptide-
flanking residues (PFRs) P-1 and P11, which lie outside the core binding sequence (P1 …

In this study, a large number of naturally processed peptides was isolated and identified
from the human diabetes-susceptible class II MHC molecules HLA-DQ8 (DQA1* 0301 …

Here we describe generation of Aw3. 18, a monoclonal antibody that recognizes peptide
residues 48–62 of hen egg lysozyme (HEL) bound to the MHC class II molecule IA k …

Polymorphisms within HLA gene loci are strongly associated with susceptibility to
autoimmune disorders; however, it is not clear how genetic variations in these loci confer a …

Nascent MHC class II molecules are associated with the invariant chain and are transported
to the endolysosomal pathway, where MHC class II molecules acquire peptide antigens. On …