Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

The emergence of immunotherapies has definitely proven the tight relationship between
malignant and immune cells, its impact on cancer outcome and its therapeutic potential. In …

Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …

Our previous research defined a novel metabolic cancer associated fibroblasts subset
(meCAFs) enriched in loose-type pancreatic ductal adenocarcinoma (PDAC) and related …

At odds with other solid tumors, epithelial ovarian cancer (EOC) is poorly sensitive to
immune checkpoint inhibitors (ICIs), largely reflecting active immunosuppression despite …

The outcome of cancer and autoimmunity is often dictated by the effector functions of CD4+
conventional T cells (Tconv). Although activation of the NF-κB signaling pathway has long …

CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although
signaling pathways leading to the activation of NF-κB transcription factors have crucial …

Objectives The relationship between bone resorption and angiogenesis in peri-implantitis
remains to be studied. We constructed a Beagle dog model of peri-implantitis, and extracted …

Abstract NF-kappaB (NF-κB) is a family of transcription factors with pleiotropic functions in
immune responses. The alternative NF-κB pathway that leads to the activation of RelB and …

Helicobacter pylori is a kind of Gram-negative bacteria that parasitizes on human gastric
mucosa. Helicobacter pylori infection is very common in human beings, which often causes …