Differential Effects of Sequence-Local versus Nonlocal Charge Patterns on Phase Separation and Conformational Dimensions of Polyampholytes as Model …
Conformational properties of intrinsically disordered proteins (IDPs) are governed by a
sequence-ensemble relationship. To differentiate the impact of sequence-local versus …
sequence-ensemble relationship. To differentiate the impact of sequence-local versus …
Nanocarriers for intracellular delivery of proteins in biomedical applications: strategies and recent advances
Protein drugs are of great importance in maintaining the normal functioning of living
organisms. Indeed, they have been instrumental in combating tumors and genetic diseases …
organisms. Indeed, they have been instrumental in combating tumors and genetic diseases …
[HTML][HTML] Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates
The rules of how amino acids dictate the physical properties of biomolecular condensates
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …
are still incomplete. Here, we study condensates formed by tetrapeptides of the form …
Direct and indirect salt effects on homotypic phase separation
The low-complexity domain of hnRNPA1 (A1-LCD) phase separates in a salt-dependent
manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is …
manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is …
[HTML][HTML] In the Beginning: Let Hydration Be Coded in Proteins for Manifestation and Modulation by Salts and Adenosine Triphosphate
J Song - International Journal of Molecular Sciences, 2024 - pmc.ncbi.nlm.nih.gov
Water exists in the beginning and hydrates all matter. Life emerged in water, requiring three
essential components in compartmentalized spaces:(1) universal energy sources driving …
essential components in compartmentalized spaces:(1) universal energy sources driving …
Mesoscale properties of biomolecular condensates emerging from protein chain dynamics
N Galvanetto, MT Ivanović, SA Del Grosso… - arXiv preprint arXiv …, 2024 - arxiv.org
Biomolecular condensates form by phase separation of biological polymers. The cellular
functions of the resulting membraneless organelles are closely linked to their physical …
functions of the resulting membraneless organelles are closely linked to their physical …
[HTML][HTML] Amino Acid-Dependent Material Properties of Tetrapeptide Condensates
Condensates formed by intrinsically disordered proteins mediate a myriad of cellular
processes and are linked to pathological conditions including neurodegeneration. Rules of …
processes and are linked to pathological conditions including neurodegeneration. Rules of …
[HTML][HTML] Phase separation drives the folding of recombinant collagen
M Shen, D Astapov, D Fedorov, T Välisalmi… - International Journal of …, 2024 - Elsevier
Recombinantly produced collagens present a sustainable, ethical, and safe substitute for
collagens derived from natural sources. However, controlling the folding of the recombinant …
collagens derived from natural sources. However, controlling the folding of the recombinant …
Direct and indirect salt effects on homotypic phase separation
MA Matt, D Souvik, Z Huan-Xiang - eLife, 2024 - search.proquest.com
The low-complexity domain of hnRNPA1 (A1-LCD) phase separates in a salt-dependent
manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is …
manner. Unlike many intrinsically disordered proteins (IDPs) whose phase separation is …
Polyphosphate Discriminates Protein Conformational Ensembles More Efficiently than DNA Promoting Diverse Assembly and Maturation Behaviors
S Goyal, D Rajendran, AK Mani, AN Naganathan - bioRxiv, 2024 - biorxiv.org
Disordered proteins and domains often assemble into condensates with polyanionic nucleic
acids, primarily via charge complementarity, regulating numerous cellular functions …
acids, primarily via charge complementarity, regulating numerous cellular functions …