Curcumin, the major constituent of Curcuma longa L.(Zingiberaceae family) or turmeric,
commonly used for cooking in Asian cuisine, is known to possess a broad range of …

Bacterial cell division is mediated by the divisome which is organized by the Z ring, a
cytoskeletal element formed by the polymerization of the tubulin homologue FtsZ. Despite …

The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …

Protein filaments are used in myriads of ways to organize other molecules within cells. Some
filament-forming proteins couple the hydrolysis of nucleotides to their polymerization cycle …

Membrane constriction is a prerequisite for cell division. The most common membrane
constriction system in prokaryotes is based on the tubulin homologue FtsZ, whose filaments …

The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form
of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site …

The continuous emergence and rapid spread of a multidrug-resistant strain of bacterial
pathogens have demanded the discovery and development of new antibacterial agents. A …

The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a
structure at the division site termed the “Z ring”. During cytokinesis, the Z ring exerts a …

How bacteria coordinate cell growth with division is not well understood. Bacterial cell
elongation is controlled by actin–MreB while cell division is governed by tubulin–FtsZ. A ring …

FtsZ polymerizes into protofilaments to form the Z-ring that acts as a scaffold for accessory
proteins during cell division. Structures of FtsZ have been previously solved, but detailed …