Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Simple Summary U2 small nuclear RNA auxiliary factor 1 (U2AF1) is one of the most
important RNA splicing genes involved in regulating the alternative splicing of pre-mRNA …

Gene mutations have not yet been included in the 2016 WHO classification and revised
International Prognostic Scoring System (IPSS-R), which are now widely utilized to …

Myelodysplastic syndrome (MDS) is a heterogeneous, clonal hematological disorder
characterized by ineffective hematopoiesis, cytopenia, morphologic dysplasia, and …

Among 1306 patients with primary myelofibrosis (PMF), we sought to identify risk factors that
predicted leukemic transformation (LT) in the first 5 years of disease and also over the …

Acute myeloid leukemia (AML) is a clonal disease caused by genetic abberations occurring
predominantly in the elderly. Next generation sequencing (NGS) analysis has led to a …

A subset of acute myeloid leukemia (AML) arises either from an antecedent myeloid
malignancy (secondary AML, sAML) or as a complication of DNA-damaging therapy for …

The diagnosis of myeloid neoplasms (MN) has significantly evolved through the last few
decades. Next Generation Sequencing (NGS) is gradually becoming an essential tool to …

To develop a genetic risk model for primary myelodysplastic syndromes (MDS), we queried
the prognostic significance of next‐generation sequencing (NGS)‐derived mutations, in the …

Myelodysplastic neoplasms are clonal hematological malignancies arising from
hematopoietic stem cells that accumulate various mutations. MDS is heterogeneous in …