[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
[HTML][HTML] Toward a wiring diagram understanding of appetite control
ML Andermann, BB Lowell - Neuron, 2017 - cell.com
Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …
regulation. This goal is now being realized through the use of recent technological …
[HTML][HTML] The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
Area postrema cell types that mediate nausea-associated behaviors
Nausea, the unpleasant sensation of visceral malaise, remains a mysterious process. The
area postrema is implicated in some nausea responses and is anatomically privileged to …
area postrema is implicated in some nausea responses and is anatomically privileged to …
Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture
Regulation of stress reactivity is a fundamental priority of all organisms. Stress responses
are critical for survival, yet can also cause physical and psychological damage. This review …
are critical for survival, yet can also cause physical and psychological damage. This review …
Preproglucagon neurons in the nucleus of the solitary tract are the main source of brain GLP-1, mediate stress-induced hypophagia, and limit unusually large intakes …
Centrally administered glucagon-like peptide 1 (GLP-1) supresses food intake. Here we
demonstrate that GLP-1–producing (PPG) neurons in the nucleus tractus solitarii (NTS) are …
demonstrate that GLP-1–producing (PPG) neurons in the nucleus tractus solitarii (NTS) are …
Enhanced AMPA receptor trafficking mediates the anorexigenic effect of endogenous glucagon-like peptide-1 in the paraventricular hypothalamus
Summary Glucagon-like Peptide 1 (GLP-1)-expressing neurons in the hindbrain send robust
projections to the paraventricular nucleus of the hypothalamus (PVN), which is involved in …
projections to the paraventricular nucleus of the hypothalamus (PVN), which is involved in …
From stress to anhedonia: molecular processes through functional circuits
Converging evidence across species highlights the contribution of environmental stress to
anhedonia (loss of pleasure and/or motivation). However, despite a clear link between …
anhedonia (loss of pleasure and/or motivation). However, despite a clear link between …
Liraglutide modulates appetite and body weight through glucagon-like peptide 1 receptor–expressing glutamatergic neurons
JM Adams, H Pei, DA Sandoval, RJ Seeley… - Diabetes, 2018 - Am Diabetes Assoc
Glucagon-like peptide 1 receptor (GLP-1R) agonists are US Food and Drug Administration–
approved weight loss drugs. Despite their widespread use, the sites of action through which …
approved weight loss drugs. Despite their widespread use, the sites of action through which …
GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats
SM Fortin, RK Lipsky, R Lhamo, J Chen… - Science translational …, 2020 - science.org
The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is approved for the
treatment of obesity; however, there is still much to be learned regarding the neuronal sites …
treatment of obesity; however, there is still much to be learned regarding the neuronal sites …