Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia, ensuring sexually …

Despite advances in the identification of chromatin regulators and genome interactions, the
principles of higher‐order chromatin structure have remained elusive. Here, we applied …

Highlights•Epigenome regulating gene expression programs underlies male germ cell
identity and spermatogenesis.•Epigenetic priming ensure the maintenance of male germ …

Paternal genomes are compacted during spermiogenesis and decompacted following
fertilization. These processes are fundamental for inheritance but incompletely understood …

Male germline stem cells (mGSCs), also known as spermatogonial stem cells (SSCs), are
the fundamental seed cells of male animal reproductive physiology. However …

PIWI-interacting RNAs (piRNAs) are small RNAs bound by PIWI-clade Argonaute proteins
that function to silence transposable elements (TEs). Following mouse primordial germ cell …

Background In mammals, primordial germ cells (PGCs), the embryonic precursors of the
germline, arise from embryonic or extra-embryonic cells upon induction by the surrounding …

Meiosis is a specialized type of cell division that occurs physiologically only in germ cells.
We previously demonstrated that MYC-associated factor X (MAX) blocks the ectopic onset of …

Topologically associating domains (TADs), megabase-scale features of chromatin spatial
architecture, are organized in a domain-within-domain TAD hierarchy. Within TADs, the …

The epigenome plays an important role in shaping phenotypes. However, whether the
environment can alter an organism's phenotype across several generations through …