Evaluation of the therapeutic potential of mesenchymal stem cells (MSCs) in preclinical models of autoimmune diseases

RK Shandil, S Dhup, S Narayanan - Stem cells international, 2022 - Wiley Online Library
Autoimmune diseases, chronic in nature, are generally hard to alleviate. Present long‐term
treatments with available drugs such as steroids, immune‐suppressive drugs, or antibodies …

The immunomodulatory effects of mesenchymal stromal cell‐based therapy in human and animal models of systemic lupus erythematosus

F Radmanesh, M Mahmoudi, E Yazdanpanah… - IUBMB …, 2020 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune inflammatory
disease with no absolute cure. Although the exact etiopathogenesis of SLE is still enigmatic …

Oxidative stress, inflammation and disease activity biomarkers in lupus nephropathy

N Bona, E Pezzarini, B Balbi, SM Daniele, MF Rossi… - Lupus, 2020 - journals.sagepub.com
Lupus nephropathy is a severe and frequent complication of systemic lupus erythematosus.
Here, we assessed the biomarkers of oxidative stress, inflammation and disease activity in …

Genetic engineering of mesenchymal stem cells to induce their migration and survival

A Nowakowski, P Walczak, B Lukomska… - Stem cells …, 2016 - Wiley Online Library
Mesenchymal stem cells (MSCs) are very attractive for regenerative medicine due to their
relatively easy derivation and broad range of differentiation capabilities, either naturally or …

Interleukin-35 and Interleukin-37 anti-inflammatory effect on inflammatory bowel disease: Application of non-coding RNAs in IBD therapy

MR Lahimchi, M Eslami, B Yousefi - International Immunopharmacology, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a widespread autoimmune disease that may even be
life-threatening. IBD is divided into two major subtypes: ulcerative colitis and Crohn's …

Efficacy of mesenchymal stem cells in animal models of lupus nephritis: a meta-analysis

T Zhou, C Liao, HY Li, W Lin, S Lin, H Zhong - Stem Cell Research & …, 2020 - Springer
Background Lupus nephritis is usually manifested by proteinuria, active urinary sediment,
hypertension, and renal failure and is a serious complication with more than 50 …

Mesenchymal stem cell transplantation in systemic lupus erythematous, a mesenchymal stem cell disorder

A Fathollahi, NB Gabalou, S Aslani - Lupus, 2018 - journals.sagepub.com
Systemic lupus erythematosus (SLE) is a chronic autoimmune and inflammatory disorder
with involvement of several organs and systems such as the kidney, lung, brain and the …

IL-37b gene transfer enhances the therapeutic efficacy of mesenchumal stromal cells in DSS-induced colitis mice

W Wang, K Dong, L Zhou, G Jiao, C Zhu, W Li… - Acta Pharmacologica …, 2015 - nature.com
Aim: To investigate whether the transfer of the IL-37b gene, a newly identified inhibitor of
both innate and adaptive immunity, could improve the therapeutic efficacy of mesenchumal …

Functional characteristics and application of mesenchymal stem cells in systemic lupus erythematosus

WY Tang, JH Liu, CJ Peng, Y Liao, JS Luo… - Archivum Immunologiae …, 2021 - Springer
Systemic lupus erythematosus (SLE) is a rare, heterogeneous autoimmune and
autoinflammatory disease that affects both sexes and all races, although this disease …

Animal models of lupus and lupus nephritis

Y Du, S Sanam, K Kate, C Mohan - Current pharmaceutical …, 2015 - ingentaconnect.com
This article reviews the commonly used murine strains for studying lupus and lupus
nephritis, including strains that develop lupus spontaneously, congenic strains, induced …