Angiogenesis plays an important role in the development of cancer since it allows for the
delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant …

Tumor angiogenesis is one of the most important processes of cancer deterioration via
nurturing an immunosuppressive tumor environment (TME). Targeting tumor angiogenesis …

Purpose Gastric cancer (GC) has high morbidity and mortality and is a serious threat to
public health. The flavonoid compound vitexin is known to exhibit anti-tumor activity. In this …

Overall, drug design is a dynamic and evolving field, with researchers constantly working to
improve their understanding of molecular interactions, develop new computational methods …

Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an
important role in cellular reprogramming processes under hypoxic conditions, which …

Inflammation therapy is particularly focused on the development of safer non-steroidal anti-
inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered …

Cancer growth is dependent on angiogenesis, the formation of new blood vessels, which
represents a hallmark of cancer. After this concept was established in the 1970s, inhibition of …

In this study, 21 new honokiol derivatives were synthesised, and their anti-cancer properties
were investigated. Among these, compound 1g exhibited the most potent cytotoxic activity …

Magnolol (MAG), a biphenolic neolignan, has various biological activities including
antitumor effects. In this study, 15 MAG derivatives were semi-synthesized and evaluated for …

To discover potential cytotoxic agents, new semi-synthetic phenoxy acetamide derivatives,
compound I and compound II, were synthesized, characterized, and screened for their …