Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery.
Some progress has been made over recent years in identifying disease-modifying therapies …

Alpha-synuclein aggregates are the hallmark pathology of Parkinson's disease, which can
propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients …

Parkinson's disease (PD) is a common neurodegenerative disorder with prominent loss of
nigro‐striatal dopaminergic neurons. The resultant dopamine (DA) deficiency underlies the …

Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's
disease. Misfolded protein aggregates in the form of Lewy bodies, comprised mainly of α …

Over the last two decades, many experimental and clinical studies have provided solid
evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to …

Glutamatergic hyperactivity in the nucleus striatum, the main basal ganglia input, has been
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced …

The appearance of motor manifestations in Parkinson's disease (PD) is invariably linked to
degeneration of nigral dopaminergic neurons of the substantia nigra pars compacta …

Parkinson's disease (PD) is considered the most common disorder of synucleinopathy,
which is characterised by intracellular inclusions of aggregated and misfolded α-synuclein …