Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Pacemaking is a basic physiological process, and the cellular mechanisms involved in this
function have always attracted the keen attention of investigators. The “funny”(I f) current …

Recent studies provide increasing evidence that postnatal neovascularization involves bone
marrow–derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

About 50 years ago, pioneering work initiated by Silvio Weidmann and others applied the
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …

Nanoscale manipulations of the extracellular microenvironment are increasingly attracting
attention in tissue engineering. Here, combining microscopy, biological, and single-cell …

Background The ideal neural interface or scaffold for stem cell therapy shall have good
biocompatibility promoting survival, maturation and integration of neural stem cells (NSCs) …

In order to govern cell-specific behaviors in tissue engineering for neural repair and
regeneration, a better understanding of material-cell interactions, especially the bioelectric …

Nanobiotechnology-enabled tissue engineering strategies have emerged as an innovative
and promising technique in the field of regenerative medical science. The design and …

Cardiac hypertrophy is characterized by electrical remolding with increased risk of
arrhythmogenesis. Enhanced abnormal automaticity of ventricular cells contributes critically …