The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

Host organisms utilise a range of genetically encoded cell death programmes in response to
pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their …

Gasdermin proteins form large membrane pores in human cells that release immune
cytokines and induce lytic cell death. Gasdermin pore formation is triggered by caspase …

Bacteria use a wide range of immune pathways to counter phage infection. A subset of these
genes shares homology with components of eukaryotic immune systems, suggesting that …

The type III-E CRISPR–Cas7-11 effector binds a CRISPR RNA (crRNA) and the putative
protease Csx29 and catalyzes crRNA-guided RNA cleavage. We report cryo–electron …

Since their discovery, members of the gasdermin (GSDM) family of proteins have been firmly
established as executors of pyroptosis, with the N-terminal fragment of most GSDMs capable …

The gasdermin family is a newly identified class of pore-forming proteins that play as the
executioners of pyroptosis, a lytic pro-inflammatory type of cell death triggered by sensing …

Pathogens have fueled the diversification of intracellular defense strategies that collectively
define cell-autonomous innate immunity. In bacteria, innate immunity is manifested by a …

A defining feature of multicellular life is the utilization of programmed cell death (PCD)[1]. By
sacrificing nonessential cells, the PCD machinery of multicellular eukaryotes defends …

In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that
induce a host cell death process called pyroptosis,–. Studies of human and mouse GSDM …