Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Early management of severe traumatic brain injury

JV Rosenfeld, AI Maas, P Bragge… - The Lancet, 2012 - thelancet.com
Severe traumatic brain injury remains a major health-care problem worldwide. Although
major progress has been made in understanding of the pathophysiology of this injury, this …

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

Y Zhang, M Chopp, Y Meng, M Katakowski, H Xin… - Journal of …, 2015 - thejns.org
OBJECT Transplanted multipotent mesenchymal stromal cells (MSCs) improve functional
recovery in rats after traumatic brain injury (TBI). In this study the authors tested a novel …

Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves …

Y Zhang, M Chopp, ZG Zhang, M Katakowski… - Neurochemistry …, 2017 - Elsevier
Multipotent human bone marrow derived mesenchymal stem cells (hMSCs) improve
functional outcome after experimental traumatic brain injury (TBI). The present study was …

Exosomes derived from bone mesenchymal stem cells ameliorate early inflammatory responses following traumatic brain injury

H Ni, S Yang, F Siaw-Debrah, J Hu, K Wu… - Frontiers in …, 2019 - frontiersin.org
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although
treatment guidelines have been developed, no best treatment option or medicine for this …

The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue …

MD Budde, L Janes, E Gold, LC Turtzo, JA Frank - Brain, 2011 - academic.oup.com
Diffusion tensor imaging is highly sensitive to the microstructural integrity of the brain and
has uncovered significant abnormalities following traumatic brain injury not appreciated …

MSCs-derived exosomes and neuroinflammation, neurogenesis and therapy of traumatic brain injury

Y Yang, Y Ye, X Su, J He, W Bai, X He - Frontiers in cellular …, 2017 - frontiersin.org
Exosomes are endosomal origin membrane-enclosed small vesicles (30–100 nm) that
contain various molecular constituents including proteins, lipids, mRNAs and microRNAs …

Intravenous autologous bone marrow mononuclear cells for ischemic stroke

SI Savitz, V Misra, M Kasam, H Juneja… - Annals of …, 2011 - Wiley Online Library
Objective: Cellular therapy is an investigational approach for stroke. Mononuclear cells
(MNCs) from the bone marrow reduce neurological deficits in animal stroke models. We …

Umbilical cord blood therapy potentiated with erythropoietin for children with cerebral palsy: a double-blind, randomized, placebo-controlled trial

K Min, J Song, JY Kang, J Ko, JS Ryu, MS Kang… - Stem Cells, 2013 - academic.oup.com
Allogeneic umbilical cord blood (UCB) has therapeutic potential for cerebral palsy (CP).
Concomitant administration of recombinant human erythropoietin (rhEPO) may boost the …

Neural stem cell therapy—Brief review

C Grochowski, E Radzikowska… - Clinical neurology and …, 2018 - Elsevier
Adult mammalian neural stem cells are unique because of their properties, such as
differentiation capacity, self-renewal, quiescence, and also because they exist in specific …