Tuberculosis: pathogenesis, current treatment regimens and new drug targets

SSR Alsayed, H Gunosewoyo - International journal of molecular …, 2023 - mdpi.com
Mycobacterium tuberculosis (M. tb), the causative agent of TB, is a recalcitrant pathogen that
is rife around the world, latently infecting approximately a quarter of the worldwide …

Infection microenvironment-related antibacterial nanotherapeutic strategies

Z Wang, X Liu, Y Duan, Y Huang - Biomaterials, 2022 - Elsevier
The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Tuberculosis drug discovery: challenges and new horizons

GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Investigation of antituberculosis, antimicrobial, anti-inflammatory efficacies of newly synthesized transition metal (II) complexes of hydrazone ligands: structural …

B Kumar, J Devi, A Dubey, A Tufail, B Taxak - Scientific Reports, 2023 - nature.com
Tuberculosis disease is a serious threat to humans and spreading quickly worldwide,
therefore, to find a potent drug, the synthesis of hydrazone ligands endowed Co (II), Ni (II) …

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

S Ehrt, D Schnappinger, KY Rhee - Nature Reviews Microbiology, 2018 - nature.com
Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13

SK Kim, MS Dickinson, J Finer-Moore, Z Guan… - Nature structural & …, 2023 - nature.com
The mycolic acid layer of the Mycobacterium tuberculosis cell wall is essential for viability
and virulence, and the enzymes responsible for its synthesis are targets for …

Life cycle progression and sexual development of the apicomplexan parasite Cryptosporidium parvum

J Tandel, ED English, A Sateriale, JA Gullicksrud… - Nature …, 2019 - nature.com
The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrhoeal
disease and an important contributor to early childhood mortality. Currently, there are no …

Benzofuran derivatives and their anti-tubercular, anti-bacterial activities

Z Xu, S Zhao, Z Lv, L Feng, Y Wang, F Zhang… - European Journal of …, 2019 - Elsevier
Benzofuran is a fundamental structural unit in a variety of biologically active natural
products, and its derivatives display various biological properties. Some benzofuran …

Recent advances of imidazole-containing derivatives as anti-tubercular agents

YL Fan, XH Jin, ZP Huang, HF Yu, ZG Zeng… - European journal of …, 2018 - Elsevier
Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

Tuberculosis: an overview of the immunogenic response, disease progression, and medicinal chemistry efforts in the last decade toward the development of potential …

A Sharma, M De Rosa, N Singla, G Singh… - Journal of medicinal …, 2021 - ACS Publications
Tuberculosis (TB) is a slow growing, potentially debilitating disease that has plagued
humanity for centuries and has claimed numerous lives across the globe. Concerted efforts …