Lung cancer is the most frequent malignant neoplasm in most countries, and the main
cancer-related cause of mortality worldwide in both sexes combined. The geographic and …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …

Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …

Lung cancer continues to be one of the most common causes of cancer death despite
understanding the major cause of the disease: cigarette smoking. Smoking increases lung …

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and
genetic determinants. We have previously identified iron-responsive element–binding …

Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Background Genetic variation increases the risk of lung cancer, but the extent to which
smoking amplifies this effect remains unknown. Therefore, we aimed to investigate the risk of …

Recent genome-wide association studies (GWASs) have identified common genetic variants
at 5p15. 33, 6p21–6p22 and 15q25. 1 associated with lung cancer risk. Several other …

The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely
unknown. To date, genome-wide association studies (GWASs) of limited size have identified …