Monoclonal antibody therapies against SARS-CoV-2
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …
Role of biologics in asthma
Patients with severe uncontrolled asthma have disproportionally high morbidity and
healthcare utilization as compared with their peers with well-controlled disease. Although …
healthcare utilization as compared with their peers with well-controlled disease. Although …
Next generation antibody drugs: pursuit of the'high-hanging fruit'
PJ Carter, GA Lazar - Nature Reviews Drug Discovery, 2018 - nature.com
Antibodies are the most rapidly growing drug class and have a major impact on human
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
health, particularly in oncology, autoimmunity and chronic inflammatory diseases. Many of …
[HTML][HTML] Mepolizumab for eosinophilic chronic obstructive pulmonary disease
Background Patients with chronic obstructive pulmonary disease (COPD) with an
eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal …
eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal …
[HTML][HTML] Interleukin-5 in the pathophysiology of severe asthma
C Pelaia, G Paoletti, F Puggioni, F Racca… - Frontiers in …, 2019 - frontiersin.org
Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …
and degranulation of eosinophils. Indeed, during the last years, significant advances have …
[HTML][HTML] Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …
vaccinees, which can be especially dangerous in hospital settings while managing frail …
Nanoparticle‐mediated delivery of inhaled immunotherapeutics for treating lung metastasis
Q Jin, W Zhu, J Zhu, J Zhu, J Shen, Z Liu… - Advanced …, 2021 - Wiley Online Library
Despite the critical breakthrough achieved by immune checkpoint blockade (ICB), the
clinical benefits are usually restricted by inefficient infiltration of immune cells and immune …
clinical benefits are usually restricted by inefficient infiltration of immune cells and immune …
World Health Organization‐defined eosinophilic disorders: 2019 update on diagnosis, risk stratification, and management
W Shomali, J Gotlib - American Journal of Hematology, 2019 - Wiley Online Library
Disease overview The eosinophilias encompass a broad range of non‐hematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …
[HTML][HTML] Biomarkers for severe eosinophilic asthma
SW Yancey, ON Keene, FC Albers, H Ortega… - Journal of allergy and …, 2017 - Elsevier
The last decade has seen the approval of several new biologics for the treatment of severe
asthma-targeting specific endotypes and phenotypes. This review will examine how …
asthma-targeting specific endotypes and phenotypes. This review will examine how …
Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …