The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

This update, written by authors designated by multiple pediatric endocrinology societies
(see List of Participating Societies) from around the globe, concisely addresses topics …

Background/Aims Central precocious puberty (CPP) is due to premature activation of the
hypothalamic-pituitary-gonadal axis. It predominantly affects girls. CPP leads to lower final …

Central precocious puberty (CPP) classically refers to premature activation of the
hypothalamic–pituitary–gonadal axis with onset of sexual development before the age of 8 …

Precocious puberty (PP) means the appearance of secondary sexual characters before the
age of eight years in girls and nine years in boys. Puberty is indicated in girls by the …

OBJECTIVE Congenital adrenal hyperplasia (CAH) can be complicated by central
precocious puberty (CPP) in children, which may compromise final height. We aimed to …

Objective. A 3‐month depot of leuprorelin acetate (LA) was introduced in China in July 2020.
However, the clinical experience is limited. The purpose of this study was to compare the …

358 V. CHIRICO ET AL. which leads to the maturation of LH and follicle stimulating hormone
(FSH) secretion and subsequently to the maturation of gonads and their activity. For the …

Ob jec ti ve: Premature thelarche (PT) refers to isolated onset of thelarche in girls younger
than 8 years of age. Most cases have an onset under 2 years of age. We aimed to establish …

Purpose: Development of incongruent secondary sex characteristics in transgender youth
can intensify or trigger the onset of gender dysphoria. Guidelines from professional …