Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …

The modulation of DNA topology by DNA gyrase and topoisomerase IV, both of which are
type IIA topoisomerases and found in most bacteria, is a function vital to DNA replication …

Bacterial DNA gyrase is a well-established and validated target for the development of novel
antibacterials. Starting from the available structural information about the binding of the …

Introduction: Bacteriological infections are a major risk to human health. These include all
hospital and public-acquired infections. In drug discovery, rhodanines are privileged …

Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin.
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …

The discovery and optimization of a new class of bacterial topoisomerase (DNA gyrase and
topoisomerase IV) inhibitors binding in the ATP domain are described. A fragment molecule …

Mur enzymes serve as critical molecular devices for the synthesis of UDP-MurNAc-
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …

In this study, we utilized human DNA topoisomerase IIα as a model target to outline a
dynophore-based approach to catalytic inhibitor design. Based on MD simulations of a …

Abstract Development of novel DNA gyrase B inhibitors is an important field of antibacterial
drug discovery whose aim is to introduce a more effective representative of this mechanistic …

Abstract Twenty-four 2-(4-oxo-2-thioxothiazolidin-3-yl) acetic acid (rhodanine-3-acetic acid)-
based amides, esters and 5-arylalkylidene derivatives were synthesized, characterized and …