Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

This brief review of the human Na/H exchanger gene family introduces a new classification
with three subgroups to the SLC9 gene family. Progress in the structure and function of this …

The SLC9 gene family encodes Na+/H+ exchangers (NHEs). These transmembrane
proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to …

Autism imposes a major impediment to childhood development and a huge emotional and
financial burden on society. In recent years, there has been rapidly accumulating genetic …

The transmembranal Na+/H+ antiporters transport sodium (or several other monovalent
cations) in exchange for H+ across lipid bilayers in all kingdoms of life. They are critical in …

We have studied a family with severe mental retardation characterized by the virtual
absence of speech, autism spectrum disorder, epilepsy, late-onset ataxia, weakness and …

Abstract NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast
and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but …

Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion
homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and …

Epilepsy is a common central nervous system (CNS) disease characterized by recurrent
transient neurological events occurring due to abnormally excessive or synchronous …

The majority of human proteins are post-translationally modified by covalent addition of one
or more complex oligosaccharides (glycans). Alterations in glycosylation processing are …