The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

▪ Abstract We describe the formation, maturation, elimination, maintenance, and
regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses …

The adult mammalian heart is non-regenerative owing to the post-mitotic nature of
cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

The postsynaptic apparatus of the skeletal neuromuscular junction, like that of other
synapses, contains a high-density patch of neurotransmitter receptors that is closely …

Neuromuscular synapse formation requires a complex exchange of signals between motor
neurons and skeletal muscle fibers, leading to the accumulation of postsynaptic proteins …

Formation of neuromuscular synapses requires a series of inductive interactions between
growing motor axons and differentiating muscle cells, culminating in the precise …

Nitric oxide (NO) is synthesized in skeletal muscle by neuronal-type NO synthase (nNOS),
which is localized to sarcolemma of fast-twitch fibers. Synthesis of NO in active muscle …

Neuromuscular junction (NMJ) formation requires agrin, a factor released from
motoneurons, and MuSK, a transmembrane tyrosine kinase that is activated by agrin …

Dystrophin is a cytoskeletal protein of muscle fibers; its loss in humans leads to Duchenne
muscular dystrophy, an inevitably fatal wasting of skeletal and cardiac muscle. mdx mice …