Alternative polyadenylation (APA) plays important roles in modulating mRNA stability,
translation, and subcellular localization, and contributes extensively to shaping eukaryotic …

Precursor message RNA requires processing to generate mature RNA. Cleavage and
polyadenylation at the 3′-end in the maturation of mRNA is one of key processing steps in …

Alternative polyadenylation (APA) enables a gene to generate multiple transcripts with
different 3′ ends, which is dynamic across different cell types or conditions. Many …

DMD pathogenic variants for Duchenne and Becker muscular dystrophy are detectable with
high sensitivity by standard clinical exome analyses of genomic DNA. However, up to 7% of …

Alternative polyadenylation can occur in introns, termed intronic polyadenylation (IPA), has
been implicated in diverse biological processes and diseases, as it can produce noncoding …

Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and
the regulation of gene expression in eukaryotic cells. While defects in pre-mRNA processing …

Regulatory processes at the RNA transcript level play a crucial role in generating
transcriptome diversity and proteome composition in human cells, impacting both …

Functional interpretation of disease-associated non-coding variants remains a significant
challenge in the post-GWAS era. Our recent study has identified 3′ UTR alternative …

Somatic single nucleotide variants (SNVs) in cancer genome affect gene expression through
various mechanisms depending on their genomic location. While somatic SNVs near …

Harnessing the patient's immune system to control a tumor is a proven avenue for cancer
therapy. T cell therapies as well as therapeutic vaccines, which target specific antigens of …