In its early stages, symptoms of chronic kidney disease (CKD) are usually not apparent.
Significant reduction of the kidney function is the first obvious sign of disease. If diagnosed …

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria
and progressive kidney failure. It is characterized by a defective glomerular basement …

Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to
a living environment of various stresses and pathological stimuli, podocytes are prone to …

Background: Podocytes, functionally specialized and terminally differentiated glomerular
visceral epithelial cells, are critical for maintaining the structure and function of the …

Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and
podocyte injury is a major cause of proteinuria in various primary and secondary …

Lipotoxicity was recently reported in several forms of kidney disease, including focal
segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is …

Human familial lecithin: cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized
by low HDL, accumulation of an abnormal cholesterol-rich multilamellar particle called …

Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional
mechanisms is involved in development of chronic kidney diseases (CKD). However, it …

Glomerular podocytes are highly differentiated cells that cover glomerular capillaries from
the outside and have a characteristic morphology with numerous foot processes. The …