The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Premature activation of digestive enzymes in the pancreas has been linked to development
of pancreatitis for more than a century. Recent development of novel models to study the …

Background & Aims Acute pancreatitis is characterized by premature intracellular activation
of digestive proteases within pancreatic acini and a consecutive systemic inflammatory …

Animal models of acute and chronic pancreatitis have been created to examine mechanisms
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long
thought to be the primary causative agent, but genetic contributions have been of interest …

Objective Acute pancreatitis is caused by toxins that induce acinar cell calcium overload,
zymogen activation, cytokine release and cell death, yet is without specific drug therapy …

The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due
to a genetic-or environment-based abnormality of intracellular acinar trypsinogen activation …

Background Chronic pancreatitis (CP) is a progressive inflammatory disorder currently
diagnosed by morphologic features. In contrast, an accurate diagnosis of Early CP is not …

Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute
pancreatitis (SAP), which increases the risk of death. AP is characterized by inappropriate …