Targeting the bone marrow microenvironment in multiple myeloma
Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in
the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal …
the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal …
Overview on the different patterns of tumor vascularization
D Ribatti, F Pezzella - Cells, 2021 - mdpi.com
Angiogenesis is a crucial event in the physiological processes of embryogenesis and wound
healing. During malignant transformation, dysregulation of angiogenesis leads to the …
healing. During malignant transformation, dysregulation of angiogenesis leads to the …
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
Increased angiogenesis has recently been recognized in active multiple myeloma (MM).
Since vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) …
Since vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) …
Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
Hematopoietic and endothelial cell lineages share common progenitors. Accordingly,
cytokines formerly thought to be specific for the hematopoietic system have been shown to …
cytokines formerly thought to be specific for the hematopoietic system have been shown to …
Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma
To assess whether the progression of plasma cell tumors is accompanied by angiogenesis
and secretion of matrix-degrading enzymes, bone marrow biopsy specimens from 20 …
and secretion of matrix-degrading enzymes, bone marrow biopsy specimens from 20 …
Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
T Padró, S Ruiz, R Bieker, H Bürger… - Blood, The Journal …, 2000 - ashpublications.org
The importance of angiogenesis for the progressive growth and viability of solid tumors is
well established. In contrast, only few data are available for hematologic neoplasms. To …
well established. In contrast, only few data are available for hematologic neoplasms. To …
Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies
WT Bellamy, L Richter, Y Frutiger, TM Grogan - Cancer research, 1999 - AACR
Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis by acting
as a potent inducer of vascular permeability as well as serving as a specific endothelial cell …
as a potent inducer of vascular permeability as well as serving as a specific endothelial cell …
Morphology of angiogenesis in human cancer: a conceptual overview, histoprognostic perspective and significance of neoangiogenesis
S Sharma, MC Sharma, C Sarkar - Histopathology, 2005 - Wiley Online Library
This paper reviews the histomorphological aspects of angiogenesis and neoangiogenesis,
quantitative and qualitative, and their applications in prognostic evaluation of neoplastic …
quantitative and qualitative, and their applications in prognostic evaluation of neoplastic …
Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin …
P Salven, A Orpana, L Teerenhovi… - Blood, The Journal of …, 2000 - ashpublications.org
High serum concentrations of vascular endothelial growth factor (S-VEGF) and basic
fibroblast growth factor (S-bFGF) are associated with unfavorable clinical characteristics in …
fibroblast growth factor (S-bFGF) are associated with unfavorable clinical characteristics in …
Endothelial cells in the bone marrow of patients with multiple myeloma
Endothelial cells (EC) were extracted through a lectin-based method from bone marrow of
57 patients with active multiple myeloma (MM) and compared with their healthy quiescent …
57 patients with active multiple myeloma (MM) and compared with their healthy quiescent …