Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

Odor signals are conveyed from the olfactory bulb to the olfactory cortex (OC) by mitral cells
(MCs) and tufted cells (TCs). However, whether and how the two types of projection neuron …

Olfactory cortex pyramidal cells integrate sensory input from olfactory bulb mitral and tufted
(M/T) cells and project axons back to the bulb. However, the impact of cortical feedback …

Rhythmic neural activity is a hallmark of brain function, used ubiquitously to structure neural
information. In mammalian olfaction, repetitive sniffing sets the principal rhythm but little is …

Sensory perception is not a simple feed-forward process, and higher brain areas can
actively modulate information processing in" lower" areas. We used optogenetic methods to …

Sensory inputs frequently converge on the brain in a spatially organized manner, often with
overlapping inputs to multiple target neurons. Whether the responses of target neurons with …

In the olfactory bulb, odor representations by principal mitral cells are modulated by local
inhibitory circuits. While dendrodendritic synapses between mitral and granule cells are …

Within the olfactory system, information flow from the periphery onto output mitral cells (MCs)
of the olfactory bulb (OB) has been thought to be mediated by direct synaptic inputs from …

Modern neuroscience has demonstrated how the adult brain has the ability to profoundly
remodel its neurons in response to changes in external stimuli or internal states. However …