In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes
in a fast and reproducible manner. Here we present the narrow-window data-independent …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

The growing trend toward high-throughput proteomics demands rapid liquid
chromatography–mass spectrometry (LC–MS) cycles that limit the available time to gather …

Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step
processes, presenting challenges with sample losses, reproducibility, requiring substantial …

Background By analyzing the proteins which are the workhorses of biological systems,
metaproteomics allows us to list the taxa present in any microbiota, monitor their relative …

We describe deep analysis of the human proteome in less than 1 h. We achieve this
expedited proteome characterization by leveraging state-of-the-art sample preparation …

Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly
correlated to β-amyloid (Aβ) and tau pathology in Alzheimer's disease (AD) brain and …

Data-independent acquisition (DIA) mass spectrometry (MS) has emerged as a powerful
technology for high-throughput, accurate, and reproducible quantitative proteomics. This …

Highlights•Recent advances in single-cell proteomics.•Improvements in sample preparation,
separation techniques, mass spectrometry instrumentation, and data acquisition/analysis.• …