Self-inflicted DNA breaks in cell differentiation and cancer
Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the
establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA …
establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA …
Nontraditional roles of DNA polymerase eta support Genome Duplication and stability
KA Eckert - Genes, 2023 - mdpi.com
DNA polymerase eta (Pol η) is a Y-family polymerase and the product of the POLH gene.
Autosomal recessive inheritance of POLH mutations is the cause of the xeroderma …
Autosomal recessive inheritance of POLH mutations is the cause of the xeroderma …
[HTML][HTML] Progression of monoclonal gammopathy of undetermined significance to multiple myeloma is associated with enhanced translational quality control and …
S Ravn Berg, A Dikic, A Sharma… - Journal of …, 2024 - … -medicine.biomedcentral.com
Despite significant advancements in treatment strategies, multiple myeloma remains
incurable. Additionally, there is a distinct lack of reliable biomarkers that can guide initial …
incurable. Additionally, there is a distinct lack of reliable biomarkers that can guide initial …
The multifaceted functions of DNA‐PKcs: implications for the therapy of human diseases
J Wu, L Song, M Lu, Q Gao, S Xu, PK Zhou, T Ma - MedComm, 2024 - Wiley Online Library
The DNA‐dependent protein kinase (DNA‐PK), catalytic subunit, also known as DNA‐PKcs,
is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well …
is complexed with the heterodimer Ku70/Ku80 to form DNA‐PK holoenzyme, which is well …