Aminopyrimidines as Syk inhibitors
MD Altman, KL Arrington, J Burch, B Cote… - US Patent …, 2014 - Google Patents
Spleen Tyrosine Kinase (Syk) is a protein tyrosine kinase which has been described as a
key mediator of immunorecep tor signalling in a host of inflammatory cells including mast …
key mediator of immunorecep tor signalling in a host of inflammatory cells including mast …
Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors
ET Romeo, MR Machacek, BW Trotter, TA Miller… - US Patent …, 2014 - Google Patents
The invention provides certain amino-pyridine-containing compounds of the Formula (I) or
pharmaceutically accept able salts thereof, wherein R, R, R, R, R, R, R, R, R, and n are as …
pharmaceutically accept able salts thereof, wherein R, R, R, R, R, R, R, R, R, and n are as …
Aminopyrimidines as SYK inhibitors
KK Childers, AM Haidle, MR Machacek… - US Patent …, 2014 - Google Patents
2013-12-16 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Bipyridylaminopyridines as Syk inhibitors
D Deschenes, MD Altman, JM Ellis, C Fischer… - US Patent …, 2015 - Google Patents
The present invention provides novel pyrimidine amines of formula I which are potent
inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment …
inhibitors of spleen tyrosine kinase, or are prodrugs thereof, and are useful in the treatment …
Substituted pyridine spleen tyrosine kinase (SYK) inhibitors
AM Haidle, SL Knowles, SD Kattar… - US Patent …, 2016 - Google Patents
2015-11-06 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Imidazolyl analogs as syk inhibitors
J Lim, MH Reutershan, JM Ellis, KK Childers… - US Patent …, 2016 - Google Patents
Int. Cl. C07D 403/12(2006.01) The present invention provides novel imidazole analogs of
C07D 403/14(2006.01) Formula I which are potent inhibitors of spleen tyrosine C07D …
C07D 403/14(2006.01) Formula I which are potent inhibitors of spleen tyrosine C07D …
Aminopyrimidines as Syk inhibitors
MD Altman, KK Childers, ME Di Francesco… - US Patent …, 2016 - Google Patents
20042O3748 WO9712871 WOO2096. 905 WOO2102313 WOO3057659 WOO3078. 404
WO2004OO5283 WO2004080463 WO2004087698 WO2004087699 WO2005O13996 …
WO2004OO5283 WO2004080463 WO2004087698 WO2004087699 WO2005O13996 …
Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
AM Haidle, MD Altman, SD Kattar… - US Patent …, 2016 - Google Patents
The invention provides certain substituted diazine and triaz ine compounds of the Formula
(I)(I) or pharmaceutically acceptable salts thereof, wherein R', RRRRC, and t are as defined …
(I)(I) or pharmaceutically acceptable salts thereof, wherein R', RRRRC, and t are as defined …
Pyridyl aminopyridines as Syk inhibitors
MD Altman, ME Di Francesco, AM Haidle… - US Patent …, 2015 - Google Patents
The present invention provides novel pyrimidine amines of formula I which are potent
inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of …
inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of …
Pyrazolyl derivatives as Syk inhibitors
MR Machacek, MD Altman, ET Romeo… - US Patent …, 2016 - Google Patents
2015-10-21 Assigned to MERCK SHARP & DOHME CORP. reassignment MERCK SHARP
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
& DOHME CORP. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …