A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

In spite of a growing body of research and data, human ageing remains a poorly understood
process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR) …

Since its inception more than four decades ago, the Mitochondrial Free Radical Theory of
Aging (MFRTA) has served as a touchstone for research into the biology of aging. The …

Abstract The Human Ageing Genomic Resources (HAGR, http://genomics. senescence. info)
is a freely available online collection of research databases and tools for the biology and …

The evolutionary meaning and basic molecular mechanisms involved in the determination of
longevity remain an unresolved problem. Currently, different theories are on offer in …

In gerontology, comparative biology of longevity offers a powerful observation point thus far
underexploited. We use this approach to evaluate the role of genetic stability in longevity …

In animal mitochondria, the four electron reduction of molecular oxygen to produce water at
respiratory complex IV is the terminal step in substrate oxidation. However, respiratory …

In evolutionary terms, life on the planet has taken the form of independently living cells for
the majority of time. In comparison, the mammalian radiation is a relatively recent event. The …

Skeletal muscle mitochondria of the African pygmy mouse Mus mattheyi exhibit markedly
reduced oxygen consumption and ATP synthesis rates but a higher mitochondrial efficiency …

The replicative life span of cell strains obtained from multiple explants from the same
individual is highly variable, additional variability is added when strains are obtained from …