Epilepsy in older people

A Sen, N Jette, M Husain, JW Sander - The Lancet, 2020 - thelancet.com
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

Cognition and dementia in older patients with epilepsy

A Sen, V Capelli, M Husain - Brain, 2018 - academic.oup.com
With advances in healthcare and an ageing population, the number of older adults with
epilepsy is set to rise substantially across the world. In developed countries the highest …

Amyloid-β: a potential link between epilepsy and cognitive decline

M Romoli, A Sen, L Parnetti, P Calabresi… - Nature Reviews …, 2021 - nature.com
People with epilepsy—in particular, late-onset epilepsy of unknown aetiology—have an
elevated risk of dementia, and seizures have been detected in the early stages of Alzheimer …

A European Academy of Neurology guideline on medical management issues in dementia

KS Frederiksen, C Cooper, GB Frisoni… - European journal of …, 2020 - Wiley Online Library
Background and purpose Dementia is one of the most common disorders and is associated
with increased morbidity, mortality and decreased quality of life. The present guideline …

Epilepsy in neurodegenerative diseases

S Neri, G Mastroianni, E Gardella, U Aguglia… - Epileptic …, 2022 - Wiley Online Library
Although epilepsy as a comorbidity in neurodegenerative disorders is increasingly
recognized, its incidence is still underestimated and the features of epilepsy in the different …

Epilepsy and Alzheimer's Disease: Potential mechanisms for an association

FS Giorgi, LF Saccaro, CL Busceti, F Biagioni… - Brain Research …, 2020 - Elsevier
Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

Association of late-onset unprovoked seizures of unknown etiology with the risk of developing dementia in older veterans

O Keret, TD Hoang, F Xia, HJ Rosen, K Yaffe - JAMA neurology, 2020 - jamanetwork.com
Importance The incidence of unprovoked seizures and epilepsy increases considerably in
late life, with approximately one-third of seizures being of unknown etiology. While …

[HTML][HTML] Mechanisms involved in epileptogenesis in Alzheimer's disease and their therapeutic implications

M Altuna, G Olmedo-Saura, M Carmona-Iragui… - International journal of …, 2022 - mdpi.com
Epilepsy and Alzheimer's disease (AD) incidence increases with age. There are reciprocal
relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an …

Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer's disease

TC Foster, C Kyritsopoulos, A Kumar - Behavioural brain research, 2017 - Elsevier
Increased human longevity has magnified the negative impact that aging can have on
cognitive integrity of older individuals experiencing some decline in cognitive function …

Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment

E Kaestner, A Reyes, A Chen, J Rao, AC Macari… - Brain, 2021 - academic.oup.com
Epilepsy incidence and prevalence peaks in older adults yet systematic studies of brain
ageing and cognition in older adults with epilepsy remain limited. Here, we characterize …