Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Antipsychotics represent the mainstay of schizophrenia pharmacological therapy, and their
role has been expanded in the last years to mood disorders treatment. Although introduced …

Currently approved antidepressant drugs often take months to take full effect, and∼ 30% of
depressed patients remain treatment resistant. In contrast, ketamine, when administered as …

Recent studies show that higher order oscillatory interactions such as cross-frequency
coupling are important for brain functions that are impaired in schizophrenia, including …

Subanesthetic doses of the psychomimetic, ketamine, have been used for many years to
elicit behavioral effects reminiscent of schizophrenia in both healthy humans and in animal …

Distinct frequency bands can be differentiated from neuronal ensemble recordings, such as
local field potentials or electrocorticogram recordings. Recent years have witnessed a rapid …

Cognitive deficits in individuals with schizophrenia (SCZ) are considered core symptoms of
this disorder, and can manifest at the prodromal stage. Antipsychotics ameliorate positive …

Neuronal firing is a fundamental element of cerebral function; and, voltage-gated potassium
(K+) channels regulate that firing through the repolarization of action potentials. Kv3-type …

Schizophrenia is a severe mental illness characterized by alterations in processes that
regulate both synaptic plasticity and functional connectivity between brain regions …

The drug ketamine has been extensively studied due to its use in anaesthesia, as a model of
psychosis and, most recently, its antidepressant properties. Understanding the physiology of …