[HTML][HTML] Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
Genetically engineered mouse models are commonly preferred for studying the human
disease due to genetic and pathophysiological similarities between mice and humans. In …
disease due to genetic and pathophysiological similarities between mice and humans. In …
GFAP in health and disease
J Middeldorp, EM Hol - Progress in neurobiology, 2011 - Elsevier
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
astrocytes, but also an important component of the cytoskeleton in astrocytes during …
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Y Lee, BM Morrison, Y Li, S Lengacher, MH Farah… - Nature, 2012 - nature.com
Oligodendroglia support axon survival and function through mechanisms independent of
myelination, and their dysfunction leads to axon degeneration in several diseases. The …
myelination, and their dysfunction leads to axon degeneration in several diseases. The …
Optimization of a GCaMP calcium indicator for neural activity imaging
Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Recent efforts in protein engineering have significantly increased the …
neuroscience. Recent efforts in protein engineering have significantly increased the …
[HTML][HTML] Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain
Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various
neurological conditions and enhance memory and cognition in humans. tDCS has gained …
neurological conditions and enhance memory and cognition in humans. tDCS has gained …
[HTML][HTML] Optogenetics in neural systems
Both observational and perturbational technologies are essential for advancing the
understanding of brain function and dysfunction. But while observational techniques have …
understanding of brain function and dysfunction. But while observational techniques have …
Channel-mediated tonic GABA release from glia
Synaptic inhibition is based on both tonic and phasic release of the inhibitory transmitter γ-
aminobutyric acid (GABA). Although phasic GABA release arises from Ca2+-dependent …
aminobutyric acid (GABA). Although phasic GABA release arises from Ca2+-dependent …
[HTML][HTML] Cell-type-specific epigenetic effects of early life stress on the brain
MF Rahman, PO McGowan - Translational Psychiatry, 2022 - nature.com
Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased
vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA …
vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA …
A role for glia in the progression of Rett's syndrome
DT Lioy, SK Garg, CE Monaghan, J Raber, KD Foust… - Nature, 2011 - nature.com
Rett's syndrome (RTT) is an X-chromosome-linked autism spectrum disorder caused by loss
of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2). Although …
of function of the transcription factor methyl-CpG-binding protein 2 (MeCP2). Although …
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
P Malatesta, E Hartfuss, M Götz - Development, 2000 - journals.biologists.com
The developing central nervous system of vertebrates contains an abundant cell type
designated radial glial cells. These cells are known as guiding cables for migrating neurons …
designated radial glial cells. These cells are known as guiding cables for migrating neurons …