The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for
both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA …

The evolutionarily conserved RNA exosome is a multisubunit ribonuclease complex that
processes and/or degrades numerous RNAs. Recently, mutations in genes encoding both …

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …

Immunoglobulin heavy chain (IgH) locus-associated G-rich long noncoding RNA (SμGLT) is
important for physiological and pathological B cell DNA recombination. We demonstrate that …

Insulators are multiprotein–DNA complexes that regulate the nuclear architecture. The
Drosophila CP190 protein is a cofactor for the DNA-binding insulator proteins Su (Hw) …

Genome organization is driven by forces affecting transcriptional state, but the relationship
between transcription and genome architecture remains unclear. Here, we identified the …

Human DIS3, the nuclear catalytic subunit of the exosome complex, contains exonucleolytic
and endonucleolytic active domains. To identify DIS3 targets genome-wide, we combined …

The exosome is an RNA-decay complex that constantly monitors transcription and
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …

Understanding cellular coordination remains a challenge despite knowledge of individual
pathways. The RNA exosome, targeting a wide range of RNA substrates, is often …

Processing and maturation of precursor RNA species is coupled to RNA polymerase II
transcription. Co‐transcriptional RNA processing helps to ensure efficient and proper …