Children and adolescents exhibit a broad range of clinical outcomes from SARS-CoV-2
infection, with the majority having minimal to mild symptoms. Additionally, some succumb to …

SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …

Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …

SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for
this outcome is unclear. Here we compare antibody and cellular immunity in children (aged …

Background Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs)
underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of …

Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe
mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with …

We study a patient with the human papilloma virus (HPV)-2-driven" tree-man" phenotype
and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2 …

Systemic and mucosal humoral immune responses are crucial to fight respiratory viral
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …

Background Children are underrepresented in the COVID-19 pandemic and often
experience milder disease than adolescents and adults. Reduced severity is possibly due to …

Severe defects in human IFNγ immunity predispose individuals to both Bacillus Calmette–
Guérin disease and tuberculosis, whereas milder defects predispose only to tuberculosis …