Aging of the cells: Insight into cellular senescence and detection Methods
NSM Kamal, S Safuan, S Shamsuddin… - European journal of cell …, 2020 - Elsevier
Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …
[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
components based on carbon-(nano) materials in the engineering of neural interfaces, to …
Structure of active human telomerase with telomere shelterin protein TPP1
Human telomerase is a RNA–protein complex that extends the 3′ end of linear
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …
Structure of human telomerase holoenzyme with bound telomeric DNA
Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere
loss that is caused by incomplete genome end replication. In humans, telomerase is …
loss that is caused by incomplete genome end replication. In humans, telomerase is …
Cryo-EM structure of substrate-bound human telomerase holoenzyme
THD Nguyen, J Tam, RA Wu, BJ Greber, D Toso… - Nature, 2018 - nature.com
The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …
telomeres during genome replication. Telomerase regulation has been implicated in cancer …
Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
Y Zhu, X Liu, X Ding, F Wang, X Geng - Biogerontology, 2019 - Springer
Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …
Demography and its effects on genomic variation in crop domestication
Over two thousand plant species have been modified morphologically through cultivation
and human use. Here, we review three aspects of crop domestication that are currently …
and human use. Here, we review three aspects of crop domestication that are currently …
The relationship between reactive oxygen species and the cGAS/STING signaling pathway in the inflammaging process
B Andrade, C Jara-Gutiérrez, M Paz-Araos… - International journal of …, 2022 - mdpi.com
During Inflammaging, a dysregulation of the immune cell functions is generated, and these
cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and …
cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and …
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus
NF Lue, C Autexier - Nature structural & molecular biology, 2023 - nature.com
Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis
of telomere repeats that protect chromosome ends. Among reverse transcriptases …
of telomere repeats that protect chromosome ends. Among reverse transcriptases …
Structure of telomerase with telomeric DNA
Telomerase is an RNA–protein complex (RNP) that extends telomeric DNA at the 3′ ends
of chromosomes using its telomerase reverse transcriptase (TERT) and integral template …
of chromosomes using its telomerase reverse transcriptase (TERT) and integral template …