Aging of the cells: Insight into cellular senescence and detection Methods

NSM Kamal, S Safuan, S Shamsuddin… - European journal of cell …, 2020 - Elsevier
Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …

[HTML][HTML] Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come?

R Rauti, M Musto, S Bosi, M Prato, L Ballerini - Carbon, 2019 - Elsevier
In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Structure of active human telomerase with telomere shelterin protein TPP1

B Liu, Y He, Y Wang, H Song, ZH Zhou, J Feigon - Nature, 2022 - nature.com
Human telomerase is a RNA–protein complex that extends the 3′ end of linear
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …

Structure of human telomerase holoenzyme with bound telomeric DNA

GE Ghanim, AJ Fountain, AMM Van Roon, R Rangan… - Nature, 2021 - nature.com
Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere
loss that is caused by incomplete genome end replication. In humans, telomerase is …

Cryo-EM structure of substrate-bound human telomerase holoenzyme

THD Nguyen, J Tam, RA Wu, BJ Greber, D Toso… - Nature, 2018 - nature.com
The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …

Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction

Y Zhu, X Liu, X Ding, F Wang, X Geng - Biogerontology, 2019 - Springer
Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

Demography and its effects on genomic variation in crop domestication

BS Gaut, DK Seymour, Q Liu, Y Zhou - Nature plants, 2018 - nature.com
Over two thousand plant species have been modified morphologically through cultivation
and human use. Here, we review three aspects of crop domestication that are currently …

The relationship between reactive oxygen species and the cGAS/STING signaling pathway in the inflammaging process

B Andrade, C Jara-Gutiérrez, M Paz-Araos… - International journal of …, 2022 - mdpi.com
During Inflammaging, a dysregulation of the immune cell functions is generated, and these
cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and …

Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus

NF Lue, C Autexier - Nature structural & molecular biology, 2023 - nature.com
Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis
of telomere repeats that protect chromosome ends. Among reverse transcriptases …

Structure of telomerase with telomeric DNA

J Jiang, Y Wang, L Sušac, H Chan, R Basu, ZH Zhou… - Cell, 2018 - cell.com
Telomerase is an RNA–protein complex (RNP) that extends telomeric DNA at the 3′ ends
of chromosomes using its telomerase reverse transcriptase (TERT) and integral template …