[HTML][HTML] Host immune response to influenza A virus infection
Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …
[HTML][HTML] Recurrent urinary tract infection: a mystery in search of better model systems
BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
Low ambient humidity impairs barrier function and innate resistance against influenza infection
In the temperate regions, seasonal influenza virus outbreaks correlate closely with
decreases in humidity. While low ambient humidity is known to enhance viral transmission …
decreases in humidity. While low ambient humidity is known to enhance viral transmission …
[HTML][HTML] The N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice and is neutralized by convalescent and post-vaccination human sera
The current COVID-19 (coronavirus disease 19) pandemic, caused by SARS-CoV-2,
disproportionally affects the elderly and people with comorbidities like obesity and …
disproportionally affects the elderly and people with comorbidities like obesity and …
[HTML][HTML] Interferon-inducible antiviral effectors
AJ Sadler, BRG Williams - Nature reviews immunology, 2008 - nature.com
Since the discovery of interferons (IFNs), considerable progress has been made in
describing the nature of the cytokines themselves, the signalling components that direct the …
describing the nature of the cytokines themselves, the signalling components that direct the …
[HTML][HTML] Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal
CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production …
CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production …
The multifunctional NS1 protein of influenza A viruses
BG Hale, RE Randall, J Ortín… - Journal of general …, 2008 - microbiologyresearch.org
The non-structural (NS1) protein of influenza A viruses is a non-essential virulence factor
that has multiple accessory functions during viral infection. In recent years, the major role …
that has multiple accessory functions during viral infection. In recent years, the major role …
[HTML][HTML] The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1/STAT signalling
H Yang, Y Dong, Y Bian, N Xu, Y Wu, F Yang… - Nature …, 2022 - nature.com
Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …
Mx proteins: antiviral gatekeepers that restrain the uninvited
Fifty years after the discovery of the mouse Mx1 gene, researchers are still trying to
understand the molecular details of the antiviral mechanisms mediated by Mx proteins. Mx …
understand the molecular details of the antiviral mechanisms mediated by Mx proteins. Mx …
[HTML][HTML] Animal models for influenza virus pathogenesis and transmission
NM Bouvier, AC Lowen - Viruses, 2010 - mdpi.com
Influenza virus infection of humans results in a respiratory disease that ranges in severity
from sub-clinical infection to primary viral pneumonia that can result in death. The clinical …
from sub-clinical infection to primary viral pneumonia that can result in death. The clinical …