Influenza A virus (IAV) is the sole cause of the unpredictable influenza pandemics and
deadly zoonotic outbreaks and constitutes at least half of the cause of regular annual …

After its recent discovery in patients with serious pneumonia in Wuhan (China), the 2019
novel coronavirus (2019-nCoV), named also Severe Acute Respiratory Syndrome …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Influenza is an acute respiratory disease in mammals and domestic poultry that emerges
from zoonotic reservoirs in aquatic birds and bats. Although influenza viruses are among the …

Many mutations disappear from the population because they impair protein function and/or
stability. Thus, amino acid positions that are essential for proper function evolve more slowly …

Influenza viruses cause annual epidemics and occasional pandemics that have claimed the
lives of millions. The emergence of new strains will continue to pose challenges to public …

Considerable progress has been made toward understanding the structural basis of the
interaction of the two major surface glycoproteins of influenza A virus with their common …

Please cite this paper as: McKimm‐Breschkin (2012) Influenza neuraminidase inhibitors:
Antiviral action and mechanisms of resistance. Influenza and Other Respiratory Viruses 7 …

The His274→ Tyr274 (H274Y) mutation confers oseltamivir resistance on N1 influenza
neuraminidase but had long been thought to compromise viral fitness. However, beginning …

Seasonal human influenza is a serious respiratory infection caused by influenza viruses that
can be found all over the world. Type A influenza is a contagious viral infection that, if left …