Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …

Human cancer genomes harbour a variety of alterations leading to the deregulation of key
pathways in tumour cells. The genomic characterization of tumours has uncovered …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of
targeted therapies and the development of high-resolution, genome-wide approaches,,,,, are …

Chromothripsis is a recently identified mutational phenomenon, by which a presumably
single catastrophic event generates extensive genomic rearrangements of one or a few …

Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

The extremities of eukaryotic chromosomes are called telomeres. They have a structure
unlike the bulk of the chromosome, which allows the cell DNA repair machinery to …

Historically, the senescent state has been associated with, and was named after, the cell-
cycle arrest that occurs after cells have undergone an intrinsically defined number of …