The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

Crucial in the regulation of many developmental pathways is a recently identified class of
DNA binding proteins, designated as helix-loop-helix (HLH) proteins. HLH proteins are …

The transcription factor PU. 1 is a hematopoietic-specific member of the ets family. Mice
carrying a mutation in the PU. 1 locus were generated by gene targeting. Homozygous …

The ets family transcription factor PU. 1 is required for the development of multiple lineages
of the immune system. Using retroviral transduction of PU. 1 complementary DNA into …

Ets is a family of transcription factors present in species ranging from sponges to human. All
family members contain an approximately 85 amino acid DNA binding domain, designated …

Publisher Summary The discovery of ets proteins as transcription factors provided a
framework for understanding the oncogenic potential of ets genes. Ets proteins became a …

THE Ets-1 proto-oncogene is a member of a transcription factor family characterized by
homology to the v-ets oncogene1á¤-4. In adult mice, Ets-1 is expressed predominantly in …

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and
among them PU. 1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the …

B lymphocyte-restricted transcription of immunoglobulin heavy-chain (IgH) genes is
specified by elements within the variable region (VH) promoter and the intronic enhancer (E …

The lymphocyte-specific DNA-binding protein LyF-1 interacts with a critical control element
in the terminal deoxynucleotidyltransferase (TdT) promoter as well as with the promoters for …