Murine single-cell RNA-seq reveals cell-identity-and tissue-specific trajectories of aging
JC Kimmel, L Penland, ND Rubinstein… - Genome …, 2019 - genome.cshlp.org
Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals
are composed of distinct cell type identities and tissue environments, but the influence of …
are composed of distinct cell type identities and tissue environments, but the influence of …
Novel insights from a multiomics dissection of the Hayflick limit
The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
senescence has become a prominent model for cellular aging in vitro. Despite decades of …
Gametogenesis: exploring an endogenous rejuvenation program to understand cellular aging and quality control
Gametogenesis is a conserved developmental program whereby a diploid progenitor cell
differentiates into haploid gametes, the precursors for sexually reproducing organisms. In …
differentiates into haploid gametes, the precursors for sexually reproducing organisms. In …
rDNA array length is a major determinant of replicative lifespan in budding yeast
The complex processes and interactions that regulate aging and determine lifespan are not
fully defined for any organism. Here, taking advantage of recent technological advances in …
fully defined for any organism. Here, taking advantage of recent technological advances in …
A genome‐scale yeast library with inducible expression of individual genes
The ability to switch a gene from off to on and monitor dynamic changes provides a powerful
approach for probing gene function and elucidating causal regulatory relationships. Here …
approach for probing gene function and elucidating causal regulatory relationships. Here …
Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
Amino acid homeostasis is critical for many cellular processes. It is well established that
amino acids are compartmentalized using pH gradients generated between organelles and …
amino acids are compartmentalized using pH gradients generated between organelles and …
Advances in quantitative biology methods for studying replicative aging in Saccharomyces cerevisiae
Aging is a complex, yet pervasive phenomenon in biology. As human cells steadily succumb
to the deteriorating effects of aging, so too comes a host of age-related ailments such as …
to the deteriorating effects of aging, so too comes a host of age-related ailments such as …
Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis
Chromatin instability and protein homeostasis (proteostasis) stress are two well-established
hallmarks of aging, which have been considered largely independent of each other. Using …
hallmarks of aging, which have been considered largely independent of each other. Using …
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
Q Liu, CE Chang, AC Wooldredge, B Fong… - Elife, 2022 - elifesciences.org
Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear
genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins …
genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins …
Senescence in yeast is associated with amplified linear fragments of chromosome XII rather than ribosomal DNA circle accumulation
A Zylstra, H Hadj-Moussa, D Horkai, AJ Whale… - PLoS …, 2023 - journals.plos.org
The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast
mother cells has been long cited as the primary driver of replicative ageing. ERCs arise …
mother cells has been long cited as the primary driver of replicative ageing. ERCs arise …