Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

The vast diversity of S100 proteins has demonstrated a multitude of biological correlations
with cell growth, cell differentiation and cell survival in numerous physiological and …

Resistance to anti-estrogen therapy is an unsolved clinical challenge in successfully treating
ER+ breast cancer patients. Recent studies have demonstrated the role of non-genetic (ie …

Rationale: Exosomes are small extracellular vesicles secreted by most cells that are found in
blood and other bodily fluids, and which contain cytoplasmic material and membrane factors …

N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA and this
methylation constitutes an important regulatory mechanism for the stability and translational …

Introduction Acquired tamoxifen resistance remains the major obstacle to breast cancer
endocrine therapy. β1-integrin was identified as one of the target genes of G protein-coupled …

In healthy tissues, cells are in mechanical homeostasis. During cancer progression, this
equilibrium is disrupted. Cancer cells alter their mechanical phenotype to a softer and more …

Orally bioavailable SERDs may offer greater systemic drug exposure, improved clinical
efficacy, and more durable treatment outcome for patients with ER-positive endocrine …

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that
lacks effective targeted therapies. The epithelial-to-mesenchymal transition (EMT) is a key …